Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation
Identifieur interne : 000736 ( Main/Exploration ); précédent : 000735; suivant : 000737Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation
Auteurs : Patricia L. Carlisle [États-Unis] ; Teja Guda [États-Unis] ; David T. Silliman [États-Unis] ; Wen Lien [États-Unis] ; Robert G. Hale [États-Unis] ; Pamela R. Brown Baer [États-Unis]Source :
- Journal of the Korean Association of Oral and Maxillofacial Surgeons [ 2234-7550 ] ; 2016.
Abstract
To validate a critical-size mandibular bone defect model in miniature pigs.
Bilateral notch defects were produced in the mandible of dentally mature miniature pigs. The right mandibular defect remained untreated while the left defect received an autograft. Bone healing was evaluated by computed tomography (CT) at 4 and 16 weeks, and by micro-CT and non-decalcified histology at 16 weeks.
In both the untreated and autograft treated groups, mineralized tissue volume was reduced significantly at 4 weeks post-surgery, but was comparable to the pre-surgery levels after 16 weeks. After 16 weeks, CT analysis indicated that significantly greater bone was regenerated in the autograft treated defect than in the untreated defect (
The presence of considerable bone healing in both treated and untreated groups suggests that this model is inadequate as a critical-size defect. Despite healing and adaptation, the original bone geometry and quality of the pre-injured mandible was not obtained. On the other hand, this model is justified for evaluating accelerated healing and mitigating the bone remodeling response, which are both important considerations for dental implant restorations.
Url:
DOI: 10.5125/jkaoms.2016.42.1.20
PubMed: 26904491
PubMed Central: 4761569
Affiliations:
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Carlisle</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Guda, Teja" sort="Guda, Teja" uniqKey="Guda T" first="Teja" last="Guda">Teja Guda</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Silliman, David T" sort="Silliman, David T" uniqKey="Silliman D" first="David T." last="Silliman">David T. Silliman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Lien, Wen" sort="Lien, Wen" uniqKey="Lien W" first="Wen" last="Lien">Wen Lien</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Robert G" sort="Hale, Robert G" uniqKey="Hale R" first="Robert G." last="Hale">Robert G. Hale</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Brown Baer, Pamela R" sort="Brown Baer, Pamela R" uniqKey="Brown Baer P" first="Pamela R." last="Brown Baer">Pamela R. Brown Baer</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26904491</idno><idno type="pmc">4761569</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761569</idno><idno type="RBID">PMC:4761569</idno><idno type="doi">10.5125/jkaoms.2016.42.1.20</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000725</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000725</idno><idno type="wicri:Area/Pmc/Curation">000725</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000725</idno><idno type="wicri:Area/Pmc/Checkpoint">000627</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000627</idno><idno type="wicri:Area/Ncbi/Merge">006424</idno><idno type="wicri:Area/Ncbi/Curation">006424</idno><idno type="wicri:Area/Ncbi/Checkpoint">006424</idno><idno type="wicri:doubleKey">2234-7550:2016:Carlisle P:investigation:of:a</idno><idno type="wicri:Area/Main/Merge">000736</idno><idno type="wicri:Area/Main/Curation">000736</idno><idno type="wicri:Area/Main/Exploration">000736</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Investigation of a pre-clinical mandibular bone notch defect model in miniature pigs: clinical computed tomography, micro-computed tomography, and histological evaluation</title><author><name sortKey="Carlisle, Patricia L" sort="Carlisle, Patricia L" uniqKey="Carlisle P" first="Patricia L." last="Carlisle">Patricia L. Carlisle</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Guda, Teja" sort="Guda, Teja" uniqKey="Guda T" first="Teja" last="Guda">Teja Guda</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Silliman, David T" sort="Silliman, David T" uniqKey="Silliman D" first="David T." last="Silliman">David T. Silliman</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Lien, Wen" sort="Lien, Wen" uniqKey="Lien W" first="Wen" last="Lien">Wen Lien</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Hale, Robert G" sort="Hale, Robert G" uniqKey="Hale R" first="Robert G." last="Hale">Robert G. Hale</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author><author><name sortKey="Brown Baer, Pamela R" sort="Brown Baer, Pamela R" uniqKey="Brown Baer P" first="Pamela R." last="Brown Baer">Pamela R. Brown Baer</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Craniomaxillofacial Regenerative Medicine, The United States Army Dental and Trauma Research Detachment, Fort Sam Houston</wicri:regionArea><wicri:noRegion>Fort Sam Houston</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of the Korean Association of Oral and Maxillofacial Surgeons</title><idno type="ISSN">2234-7550</idno><idno type="eISSN">2234-5930</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To validate a critical-size mandibular bone defect model in miniature pigs.</p></sec><sec><title>Materials and Methods</title><p>Bilateral notch defects were produced in the mandible of dentally mature miniature pigs. The right mandibular defect remained untreated while the left defect received an autograft. Bone healing was evaluated by computed tomography (CT) at 4 and 16 weeks, and by micro-CT and non-decalcified histology at 16 weeks.</p></sec><sec><title>Results</title><p>In both the untreated and autograft treated groups, mineralized tissue volume was reduced significantly at 4 weeks post-surgery, but was comparable to the pre-surgery levels after 16 weeks. After 16 weeks, CT analysis indicated that significantly greater bone was regenerated in the autograft treated defect than in the untreated defect (<italic>P</italic>=0.013). Regardless of the treatment, the cortical bone was superior to the defect remodeled over 16 weeks to compensate for the notch defect.</p></sec><sec><title>Conclusion</title><p>The presence of considerable bone healing in both treated and untreated groups suggests that this model is inadequate as a critical-size defect. Despite healing and adaptation, the original bone geometry and quality of the pre-injured mandible was not obtained. On the other hand, this model is justified for evaluating accelerated healing and mitigating the bone remodeling response, which are both important considerations for dental implant restorations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mitchener, Ta" uniqKey="Mitchener T">TA Mitchener</name></author><author><name sortKey="Canham Chervak, M" uniqKey="Canham Chervak M">M Canham-Chervak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lew, Ta" uniqKey="Lew T">TA Lew</name></author><author><name sortKey="Walker, Ja" uniqKey="Walker J">JA Walker</name></author><author><name sortKey="Wenke, Jc" uniqKey="Wenke J">JC Wenke</name></author><author><name sortKey="Blackbourne, Lh" uniqKey="Blackbourne L">LH Blackbourne</name></author><author><name sortKey="Hale, Rg" uniqKey="Hale R">RG Hale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owens, Bd" 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Yin</name></author><author><name sortKey="Gui, L" uniqKey="Gui L">L Gui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Weijden, F" uniqKey="Van Der Weijden F">F Van der Weijden</name></author><author><name sortKey="Dell Acqua, F" uniqKey="Dell Acqua F">F Dell'Acqua</name></author><author><name sortKey="Slot, De" uniqKey="Slot D">DE Slot</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Carlisle, Patricia L" sort="Carlisle, Patricia L" uniqKey="Carlisle P" first="Patricia L." last="Carlisle">Patricia L. Carlisle</name></noRegion><name sortKey="Brown Baer, Pamela R" sort="Brown Baer, Pamela R" uniqKey="Brown Baer P" first="Pamela R." last="Brown Baer">Pamela R. Brown Baer</name><name sortKey="Guda, Teja" sort="Guda, Teja" uniqKey="Guda T" first="Teja" last="Guda">Teja Guda</name><name sortKey="Guda, Teja" sort="Guda, Teja" uniqKey="Guda T" first="Teja" last="Guda">Teja Guda</name><name sortKey="Hale, Robert G" sort="Hale, Robert G" uniqKey="Hale R" first="Robert G." last="Hale">Robert G. Hale</name><name sortKey="Lien, Wen" sort="Lien, Wen" uniqKey="Lien W" first="Wen" last="Lien">Wen Lien</name><name sortKey="Silliman, David T" sort="Silliman, David T" uniqKey="Silliman D" first="David T." last="Silliman">David T. Silliman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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